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Det drejer sig om DNA og RNA

Note that each phosphodiester bridge has a negativ charge. This negative charge repels nucleophilic species such as hydroxide ions. Det forstår jeg.

Phosphodiester linkages are much less susceptible to hydrolytic attack than are other esters such as carboxylic acid esters .det jeg har forstået er at de ikke kan lide vand, men at de er mere modtagelige over for carboxylsyreester...

This resistance is crucial for maintaining the integrity of information sotres in nucleic acids. det forstår jeg ikke. hvilken modstand taler de om?

og fordi DNA mangler OH øges denne modstand?