Ubiquitin

03. november 2013 af Juniblomsten (Slettet) - Niveau: Universitet/Videregående

Ubiquitin is highly conserved. Between human and yeast ubiquitin there are only 3 substitutions (see the Blast search results below).

Blast search of human ubiquitin (query) against yeast ubiquitin (subject)

Query 1 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN 60

MQIFVKTLTGKTITLEVE+SDTI+NVK+KIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN

Subject 1 MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN 60

Query 61 IQKESTLHLVLRLRGG 76

IQKESTLHLVLRLRGG

Subject 61 IQKESTLHLVLRLRGG 76

Where are these substitutions located in the elements of the protein? Compare the properties of the amino acid substitutions.

Comment on the potential consequences of these changes (if any) relative to their location in the protein structure.

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