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Dissolution rate

11. juni kl. 17:53 af Zhraaa - Niveau: Universitet/Videregående

Er der nogen der kan hjælpe med følgende?

Let us consider an API that has crystals forming regular cubes of an average particle size of 0.1 mm. It may further be given that this material dissolves (after Noyes Whitney rules) at a dissolution rate of 10 mg/min. If the material was comminuted to an average particle size of 50 µm, what would the (estimated) dissolution rate become (under identical experimental conditions)?


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