Biologi

Hjælp hvad er HI titer? haster

28. november 2022 af Lara45 - Niveau: A-niveau

Opgave: Diskuter brugen af antistofmåling i forbindelse med influenzavirusinfektion 

Facit
Antistofmåling er ikke egnet til diagnostik af akut influenzainfektion, men kan anvendes til vurdering af influenzaimmunitet, da en vis HI titer (>40) overfor den relevante virusstamme indikerer klinisk beskyttende, bruges i forbindelse med vurdering af vaccine effekt eller immunitet overfor nyintroducerede stammer.

Hvad er HI titer? 

Jeg har simpelthen søgt og søgt, men forgæves. Håber nogle kan hjælpe


Brugbart svar (1)

Svar #1
29. november 2022 af AngelOneOne

Hej,

HI står for Hemagglutination Inhibition, og er en titreringsmetode der anvendes for at måle antistof-reaktioner mod virusinfektioner.

PubMed skriver:

The hemagglutination inhibition (HI) assay for influenza A virus has been used since the 1940s. The assay may be utilized to detect or quantify antibodies to influenza A viruses and can be used to characterize differences in antigenic reactivity between influenza isolates. In addition, data from HI assays are routinely used for antigenic cartography, influenza virus surveillance, epidemiology, and vaccine-seed strain selection. For antibody quantification, the HI assay is a fast and inexpensive method; other than a source of red blood cells, no expensive or unusual lab equipment is needed, and results can be obtained within a few hours. Historically, the HI assay has also served as a primary method of subtype identification and is still used widely. However, as gene sequencing technology has evolved to be cheaper and faster, it is replacing the HI assay for this purpose.

Og Wikipedia har en artikel om det her: https://en.wikipedia.org/wiki/Hemagglutination_assay

/Angel

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